Extreme BP lowering that have extra doses out of potassium on the diversity out of 1900 in order to 4700 milligrams/d (49–122 mmol/d) Klick jetzt could have been said to effect a result of BP decrease in approximately dos in order to 6 mm hg getting diastolic BP and you may 2 to 4 mm hg to possess systolic BP. the new higher variability anywhere between results reflects brand new variability observed in various other training. on top of that, the end result off potassium for the BP is actually dependent on pretreatment BP level; age; race; sex; comorbid standards; consumption regarding sodium, magnesium, calcium, and other ions; diet; exercise; weight; sort of potassium put; concomitant medicines; and you may lifetime of play with. a listing of the findings of all the meta-analyses towards results of potassium on the BP so far try considering during the Contour step 3.

Post on meta-analyses out of degree examining the blood circulation pressure-reducing results of potassium. 25–twenty eight SBP means systolic blood pressure levels; DBP, diastolic blood pressure.

Though conflicting abilities regarding your negative effects of potassium supplements on BP was indeed reported into the scientific studies, 34, thirty five more recent trials have showed efficiency in line with that the brand new meta-data by Whelton and acquaintances twenty-six (Table II). Gu and you may colleagues thirty six unearthed that reasonable potassium supplements (sixty mmol KCl) pulled having a dozen months led to a decrease in systolic BP, but not diastolic BP, for the a beneficial Chinese people. Furthermore, Kawano and you will associates 37 documented that a cuatro-week potassium supplements months (during which 64 mmol/d out of potassium received since the slow-release KCl) led to short however, extreme reductions within the work environment, house, and you will twenty four-hr BP for the Japanese men. Braschi and you may colleagues 38 then checked out the end result out of lower-dosage potassium supplementation toward BP and found that twenty-four mmol/d out-of sluggish-discharge KCl administered having six weeks led to tall reductions inside mean arterial tension and you may diastolic BP during the match volunteers.

Elements for which Potassium Lowers BP

New homeostasis out of sodium and you may potassium performs a crucial role into the endothelium-centered vasodilatation. 39 Sodium maintenance reduces the synthesis from nitric oxide, a keen arteriolar vasodilator elaborated by the endothelial cells, and you can boosts the plasma amount of asymmetric dimethyl-L-arginine, a keen endogenous inhibitor off nitric oxide design. forty a nutrition full of potassium and expands in the serum potassium, also in physiological diversity, end up in endothelium-based vasodilatation by hyperpolarizing the new endothelial cell compliment of stimulation of salt push and you may beginning potassium avenues. 41 As well, most other proposed systems in which potassium can also be influence BP tend to be natriuresis, modulation of baroreceptor sensitiveness, reduced vasoconstrictive susceptibility to norepinephrine and you will angiotensin II, improved solution and urinary kallikrein, enhanced sodium/potassium Within Pase hobby, modification when you look at the DNA synthesis, and you may proliferation during the vascular simple strength and you may sympathetic nervous system tissues. 42, 43

Slimming down Assistance to own Potassium

Maintaining an adequate intake of dietary potassium (>90 mmol [3500 mg]/d) has been recommended for the primary prevention of hypertension by the JNC 7.13 The Institute of Medicine has recommended a sodium intake <65 mmol/d (3.8 g/d) and an increase in potassium to 120 mmol/d. 44 In 2006, the American Heart Association issued new guidelines suggesting an increase in potassium intake to 120 mmol/d (4.7 g/d), which is the level provided in the DASH diets in which all food is supplied. 14 The Canadian Hypertension Society recommends that the daily dietary intake of potassium should be ?60 mmol, since this intake has been associated with a reduced risk of stroke-related mortality. 45, 46 The most recent European Society of Hypertension guidelines also support an increased potassium intake based on the DASH diet. 18 In addition, the 2003 World Health Organization/International Society of Hypertension statement recommends a diet high in fruits and vegetables, a reduction of dietary sodium intake, and increased dietary potassium intake for reducing the incidence of hypertension. 16 Some sources of high-potassium, low-sodium foods are listed in Table III. 47